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Contact Info

Danielle Benoit, Ph.D. Department of Biomedical Engineering University of Rochester work Rochester, NY 14627-0168 office: Goergen Hall 308 p 585-273-2698 f Benoit

Recent Publications

  • (2014 Aug). Degradable hydrogels for spatiotemporal control of mesenchymal stem cells localized at decellularized bone allografts. - Acta biomaterialia.
  • (2014 Jul 14). Poly(styrene-alt-maleic anhydride)-Based Diblock Copolymer Micelles Exhibit Versatile Hydrophobic Drug Loading, Drug-Dependent Release, and Internalization by Multidrug Resistant Ovarian Cancer Cells. - Biomacromolecules.
  • (2013 Dec). Dynamic manipulation of hydrogels to control cell behavior: a review. - Tissue engineering. Part B, Reviews.
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Graduate Students

  • Photo of Michael Baranello

    Michael Baranello

    Use of Polymer Micelles to Enhance Cancer Therapeutics (Supported by an NSF graduate research fellowship)

  • Photo of Michael-John Beltejar

    Michael-John Beltejar

    Regenerative Medicine

  • Photo of Michael Hoffman

    Michael Hoffman

    Tissue Engineered Periosteum Approaches to Heal Bone Allograft Transplants (Supported by an NIH T32 training grant 'Training in Orthopaedics')

  • Photo of Chris Schmitt

    Chris Schmitt

    Bone Homing Polymer Therapeutics

  • Photo of Andrew Shubin

    Andrew Shubin

    Developing hydrogels for the regeneration of salivary glands

  • Photo of Amy Van Hove

    Amy Van Hove

    Stimuli-responsive delivery of therapeutic peptide drugs (Supported by an HHMI Med-Into-Grad Fellowship)

Danielle Benoit

  • Ph.D., University of Colorado, 2006
Photo of Danielle Benoit
  • Assistant Professor

    • Biomedical Engineering
    • Chemical Engineering
    • Center for Musculoskeletal Research
    • UR Stem Cell and Regenerative Medicine Institute

Benoit Lab

Research Overview

Our lab works at the interface of medicine and engineering, with an emphasis on precisely controlling biomaterial functionality and architecture to treat diseases, control cell behavior, or answer fundamental biological questions. In particular, we are focusing on two avenues: synthetic hydrogels with tunable degradation and mechanical properties as a synthetic extracellular matrix analogue for the culture and delivery of cells for regenerative medicine approaches and polymers formed using reversible-addition fragmentation chain transfer polymerization (RAFT), a controlled, living polymerization strategy, designed with drug delivery applications in mind. Our overall hypothesis is that by using bottom-up approaches, we can design 'smart' materials with distinct capabilities, such as controlling cell behavior or overcoming delivery barriers.