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Contact Info

Kelley S. Madden, Ph.D. Department of Biomedical Engineering University of Rochester work Box 603 601 Elmwood Ave Rochester, NY 14642 office: MC 5-7220 p 585-273-5724 f 585-276-2254 Madden

Recent Publications

  • (2013 Dec). The antidepressant desipramine and α2-adrenergic receptor activation promote breast tumor progression in association with altered collagen structure. - Cancer prevention research (Philadelphia, Pa.).
  • (2013 Aug). Tumor-associated macrophages and stromal TNF-α regulate collagen structure in a breast tumor model as visualized by second harmonic generation. - Journal of biomedical optics.
  • (2013 Mar). Brain tumor imaging: imaging brain metastasis using a brain-metastasizing breast adenocarcinoma. - Cold Spring Harbor protocols.
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Kelley S. Madden

  • Ph.D., University of Rochester, 1989
Photo of Kelley Madden
  • Research Assistant Professor

    • Biomedical Engineering

Brown Lab

Research Overview

In breast cancer patients, chronic emotional stress is an unfortunate accompaniment to the physiological toll of the cancer itself. In laboratory animals, exposure to stressful situations, such as surgery, social isolation, or restraint, can accelerate tumor growth, but the biological mechanisms are not clear. We propose that release of norepinephrine, a sympathetic nervous system neurotransmitter released by stressor exposure, can promote tumor growth by facilitating the growth of new tumor blood vessels (angiogenesis). We will examine the role sympathetic nervous system activation plays in tumor pathology by assessing angiogenesis, and pro-angiogenenic pathways in vitro and in vivo. These experiments take advantage of a unique combination of abilities and interests in our laboratory, including expertise in the neuroendocrine response to stress, as well as an established research program pioneering the use of powerful new microscope technologies to study tumor biology in general and breast cancer angiogenesis in particular. Our results will provide insight into the role that stress plays in breast tumor growth and will begin to elucidate the underlying mechanisms. These experiments will also lay the foundation for future experiments studying how stress-induced neurotransmitters and hormones signal malignant and host cells and influence tumor growth. Inhibiting the host stress response may be an additional tool to retard breast cancer growth in humans