Diane Dalecki - Current Research
Therapeutic Applications of Ultrasound
Ultrasound transducer and exposure chamber.
Ongoing work in the Dalecki lab is dedicated to discovering and advancing novel therapeutic applications of ultrasound. Therapeutic applications of ultrasound depend upon the direct interaction of the sound field with the tissue to produce the desired effect. For example, lithotripsy is the use of high intensity acoustic shock waves to fragment kidney stones non-invasively.
Many new ultrasound therapies are on the horizon, including drug delivery, wound healing, thrombolysis, high intensity focused ultrasound surgery, and gene transfection. Efforts focus on understanding the fundamental molecular, cellular, and physical mechanisms underlying therapeutic ultrasound approaches. Knowledge of basic mechanisms provides the power to design optimized exposure parameters, identify synergistic therapies, and engineer exposure systems that maximize the therapeutic effects of ultrasound while minimizing adverse side effects.