Cell & Tissue Engineering
Smart Bandage - a nanocomposite biosensor comprised of a porous silicon sensor membrane supported by a therapeutic hydrogel sheet.
One of the most exciting areas in biomedical engineering is
tissue engineering, the ability to generate
living tissue ex vivo for replacement or therapeutic applications through materials development, biochemical
manipulations, cell culture, and genetic engineering. This area of research and development has the potential
to revolutionize the treatment of a wide variety of disorders and injuries. Of fundamental importance in the
design of such tissues is the ability to understand and predict how cell behavior, cell growth, and differentiation
are affected by the mechanochemistry of the cellular environment. There is ample evidence showing that the physical
surroundings of cells, both chemical and mechanical, can have profound effects on cellular behavior, including growth
and differentiation. Of particular importance is first understanding, then controlling, the effects of physical
contacts between cells, between cells and artificial substrates, and between cells and the extracellular matrix
that they produce. Molecular, Cellular & Tissue Engineering encompasses the study of cellular interactions
using principles of engineering, physical chemistry, and physics to more clearly understand the mechanism of
cellular responses to surface contacts. It includes the design of surfaces for the purpose of eliciting a particular
cellular response, and it includes the application of this knowledge to generate cellular systems for therapeutics,
sensors, and novel tools for research.
URMC has a distinguished history of musculoskeletal research led by experienced physicians and biomedical scientists. The creation of the Center for Musculoskeletal Research in 2000 formalized a 25-year history of multidisciplinary, comprehensive research for bettering musculoskeletal health for the patients of today and tomorrow.