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Tissue Engineered Periosteum Approaches to Heal Bone Allograft Transplants

Although most orthopaedic fractures heal, the clinical management of critical (>3mm) segmental defects continues to present major challenges for both amputation and limb salvage approaches. The periosteum plays an essential role in the healing process of both fractures and autografts. Periosteal stem cells have been shown necessary for the induction of robust endochondral and intramembraneous bone formation, essential for effective healing and neovascularization of autografts.