BME PhD Proposal Seminar: Drew Scoles

Towards High Resolution Broadband Retinal Imaging

Co-Supervised by Prof. Alfredo Dubra & Prof. David Williams

Abstract

Today, non-invasive optical imaging is the cornerstone of ophthalmologic diagnosis and monitoring. Recent inventions including adaptive optics (AO) and optical coherence tomography (OCT) allow for microscopic views of the living human retina in health and disease. When using multiple wavelengths of light, these techniques are limited in their spatial resolution by the longitudinal chromatic aberration (LCA) of the optics of the eye. This limitation prevents the visualization of microscopic retinal structures affected in the most prevalent blinding diseases, including glaucoma and age related macular degeneration. The goals of the work proposed next are: a) to develop LCA correction technology that accounts for intersubject anatomical differences, b) to demonstrate adaptive LCA correction in a multiwavelength adaptive optics scanning light ophthalmoscope (AOSLO) and c) to use this instrument to study inner retinal structures in healthy and diseased eyes.