BME Seminar Series: Kelley S. Madden
Sympathetic Nervous System Regulation of Breast Cancer: Potential Role for Tumor Fibrillar Collagen as Detected by Multiphoton Second Harmonic Generation
The sympathetic nervous system (SNS) can facilitate cancer growth and metastasis through norepinephrine and epinephrine activation of adrenergic receptors. Breast cancer pathogenesis involves interactions between tumor cells and host stromal cells, including cells of the immune system, fibroblasts, and endothelial cells. These stromal cell populations express adrenergic receptors, and thus are potential targets of SNS activation within the tumor or in extra-tumoral sites. Our results suggest novel SNS-stromal cell interactions that modulate tumor fibrillar collagen as detected by multiphoton second harmonic generation. The implications of this research for developing new strategies for safe and effective treatment of metastastic breast cancer will be discussed.