BME Seminar Series: Robert T. Tranquillo
Cardiovascular Tissue Engineering Based on Cell-Remodeled Biopolymers
We are attempting to develop engineered cardiovascular tissues based on the approach of entrapping cells when forming a fibrin gel within an appropriate mold. The cell induced contraction of the network of native protein fibrils is harnessed by applying appropriate mechanical constraints to obtain the desired alignment of fibrils and cells, that which is characteristic of the target tissues. Application of these strategies to a tissue-engineered heart valve and artery, including recent implant studies, and a microvascularized tissue are highlighted.